The Cochrane Database of Systematic Reviews (CDSR) is the leading resource for systematic reviews in health care. The CDSR includes Cochrane Reviews (the systematic reviews) and protocols for Cochrane Reviews as well as Editorials.
Updated: 20 min ago
Chemotherapy is established as an effective therapy for early breast cancer, reducing recurrence rates and improving survival. It was postulated that higher doses of treatment might be more effective. An updated Cochrane Review includes data from extended follow-up from existing trials, and we now have high-quality evidence that high-dose chemotherapy does not improve survival in breast cancer.
Two new and very different Cochrane Reviews illustrate some key pragmatic decisions taken to enhance the relevance of review findings to clinical practice. Both reviews shifted away from the more exacting inclusion criteria initially implied in their scopes to reflect clinical reality, and thus increase the applicability of the findings.