The Cochrane Database of Systematic Reviews (CDSR) is the leading resource for systematic reviews in health care. The CDSR includes Cochrane Reviews (the systematic reviews) and protocols for Cochrane Reviews as well as Editorials.
Updated: 23 min 11 sec ago
Receiving a kidney transplant is transformative for a patient who is on dialysis. Transplantation means a major operation, short-term and long-term monitoring, and multiple drugs to prevent rejection of the new organ, but it also brings the promise of a more normal life. Corticosteroids have been one of the mainstays for preventing rejection since the inception of solid organ transplantation, but reducing the risk of rejection needs to be carefully balanced against the harms of corticosteroids. An updated Cochrane Review provides more information on this important topic.
Chemotherapy is established as an effective therapy for early breast cancer, reducing recurrence rates and improving survival. It was postulated that higher doses of treatment might be more effective. An updated Cochrane Review includes data from extended follow-up from existing trials, and we now have high-quality evidence that high-dose chemotherapy does not improve survival in breast cancer.