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Clinical studies (registration, methodology, etc.)

This selection of resources does not aim to be comprehensive, but it is updated regularly, and we welcome suggestions for additions at


Friedman LM, Furberg CD, DeMets DL. Fundamentals of clinical trials. 3. ed. - New York ; Heidelberg: Springer, 1998. ISBN 0-387-98586-7


De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, et al. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Ann Intern Med. 2004;141:477-8. Epub 2004 Sep 8.

Grimes DA, Schulz KF. An overview of clinical research: the lay of the land. The Lancet 2002; 359(9300):57-61

Is This Clinical Trial Fully Registered? A Statement from the International Committee of Medical Journal Editors. May 2005 Update on Trials Registration in ICMJE.

Kitto S, Villanueva EV, Chesters J, Petrovic A, Waxman BP, Smith JA. Surgeons' Attitudes towards and Usage of Evidence-based Medicine in Surgical Practice: a Pilot Study. ANZ J Surg 2007; 77:231-36

Mathieu S, Boutron S; Moher D et al. Comparison of Registered and Published Primary Outcomes in Randomized Controlled Trials. JAMA. 2009;302(9):977-984 (doi:10.1001/jama.2009.1242)

Moreno SG et al. Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications. BMJ. 2009;339:b2981, doi:10.1136/bmj.b2981

Pildal J, Hrobjartsson A, Jorgensen KJ, Hilden J, Altman DG, Gotzsche GC. Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. Int J Epidemiol. 2007;36:847-57

Reed DA, Cook DA, Beckman TJ, Levine RB, Kern DE, Wright SM. Association Between Funding and Quality of Published Medical Education Research. JAMA. 2007;298(9):1002-9

Cochrane Methodology Register

The Cochrane Methodology Register (CMR) is a bibliography of publications that report on methods used in the conduct of controlled trials. It includes journal articles, books, and conference proceedings, and the content is sourced from MEDLINE and hand searches. The CMR is currently under review, and its last update incorporated into the July issue 2012

Organisations & resources

ANZCTR: Australian New Zealand Clinical Trials Registry
CIHR: Canadian Institutes of Health Research: Registration of RCTs
Cancer Clinical Trials
(Clinical Trials Listing Service) (Clinical Trials der US Medical Library of Medicine)
Cochrane Renal Group Prospective Trials Registration
CRD-Liste:Forschungsregister Centre for Reviews and Dissemination
CCT: Current Controlled Trials (International Standard Randomised Controlled Trial Number Registry)
Deutsches Register für Klinische Studien
eudraCT ( European Clinical Trials Database)
European Science Foundation (press release)
ICMJE: International Committee of Medical Journal Editors (statement)
ICTRP (WHO International Clinical Trials Registry Platform)
US National Cancer Institute

Updated on: October 24, 2013, 13:04

Comments for improvement or correction are welcome.